
Lymphoma is a pretty common cancer in cats that attacks their lymphatic system.
It can pop up in different spots, so the symptoms don’t always look the same. The main signs to watch for are weight loss, loss of appetite, vomiting, diarrhea, and swollen lymph nodes.
Since these symptoms can be sneaky or look like other problems, a lot of cat owners miss them at first.
Some cats act tired or have a hard time breathing if the cancer spreads to their chest.
Knowing what to watch for really helps you spot issues early and get your cat the care they need.
This article goes over the top symptoms of lymphoma in cats so you can catch warning signs and understand what’s going on.
Recognizing Symptoms of Lymphoma in Cats
Lymphoma in cats comes with a bunch of symptoms, and they really depend on where the cancer shows up.
The signs usually mess with eating, energy, and sometimes certain body parts.
Figuring out what’s normal and what’s not can help you catch problems sooner.
Common Signs and Clinical Symptoms
Cats with lymphoma often drop weight, even if they keep eating at first.
As things get worse, their appetite usually tanks or disappears.
Vomiting and diarrhea happen a lot, especially if the intestines get involved.
Tiredness is another big clue.
Your cat might not want to play or move around much.
If lymphoma hits the kidneys, you might notice your cat drinks more or pees differently.
You might also feel swollen lymph nodes or find lumps under their skin.
Nasal lymphoma can cause sneezing, stuffy nose, or a swollen face.
If you spot any of these, it’s probably time to call your vet.
Understanding Types and Affected Areas
Lymphoma can show up in lots of places in a cat’s body.
The usual spots are the lymph nodes, gut, nose, kidneys, and organs like the thymus or spleen.
Here are the main types:
- Gastrointestinal lymphoma affects the stomach and intestines.
- Mediastinal lymphoma shows up in the chest, near the thymus.
- Renal lymphoma goes after the kidneys.
- Nasal lymphoma targets the nose and nearby tissues.
- Multicentric lymphoma means it’s in several lymph nodes or organs.
Doctors also sort lymphoma by how fast it grows:

- Small cell (low-grade) lymphoma moves slowly and usually comes with milder symptoms.
- Large cell (high-grade) lymphoma grows fast and can make your cat sick quickly.
Progression and Impact on Quality of Life
As the cancer gets worse, symptoms usually get more obvious.
Weight loss and poor appetite hit harder.
If the intestines are involved, your cat might struggle to get nutrients, leading to ongoing diarrhea or vomiting.
When lymphoma affects the kidneys, you’ll probably see changes in urination and thirst.
Nasal lymphoma can make breathing tough because of swelling or congestion.
How much the cancer affects a cat’s life really depends on the type and where it’s located.
Low-grade lymphoma can let cats live longer with treatment and fewer symptoms.
High-grade lymphoma often moves quickly but sometimes responds to chemo.
Pay attention to changes in how your cat eats, their energy, or any new lumps or breathing trouble.
Staying alert can really help you care for your cat.
For more info on symptoms and types, check out Feline lymphoma: diagnosis, staging and clinical presentations.
Diagnosis and Treatment Pathways for Feline Lymphoma
Vets need to run a few tests to figure out what type of lymphoma your cat has and how far it’s spread.
What happens next depends on your cat’s health, where the cancer is, and how they respond to treatment.
Cost and possible side effects also make a difference when picking a plan.
Diagnosis and Staging
Vets start by checking your cat and asking about their health history.
They usually use a fine needle aspirate or biopsy to look for lymphoma cells.
Imaging like ultrasound helps them see if organs or lymph nodes are affected.
Blood tests and urinalysis show how well your cat’s organs are working.

Staging tells if the lymphoma is just in one spot or has spread.
This step helps the vet pick the right treatment and gives you an idea of what to expect.
Treatment Options and Supportive Care
Most cats with lymphoma get chemotherapy, often managed by a veterinary oncologist.
Common meds are chlorambucil and prednisolone (a steroid).
Oral chemo can make things easier at home.
Sometimes vets use radiation therapy or surgery if the cancer is only in one place.
Supportive care helps manage things like nausea or not wanting to eat.
If remission isn’t possible, some cats get palliative care to keep them comfortable.
Associated Viral Infections
A lot of cats with lymphoma test positive for feline leukemia virus (FeLV) or feline immunodeficiency virus (FIV).
These viruses weaken the immune system and raise the risk of lymphoma.
Vets test for FeLV and FIV as part of diagnosis because these viruses can change the treatment plan.
You can help prevent infections by vaccinating your cat and keeping them away from infected cats.
Prevention and Prognosis for Cats With Lymphoma
To help prevent lymphoma, keep your cat indoors and make sure they get their FeLV shots.
Catching it early usually gives better odds for remission, but it really depends on the type and stage.
Outlook varies a lot.
Cats with high-grade lymphoma often need stronger treatment, while low-grade lymphoma can sometimes be managed for longer.
It’s important to think about costs and your cat’s quality of life when making decisions.
Frequently Asked Questions
Lymphoma in cats usually shows up as changes in appetite, weight, or energy.
Changes in urination, digestion, or behavior are also important to notice.
What are the initial indicators of lymphoma in our feline friends?
Early on, you might see weight loss and less interest in food.
Cats can seem more tired or not as playful.
Swelling or lumps, especially around lymph nodes, can be a clue.
If the cancer affects the throat or chest, breathing or swallowing might get tough.
Which illnesses have similar presentations to lymphoma in cats?
Kidney disease and infections can look a lot like lymphoma, with weight loss and poor appetite.
Other cancers or inflammatory diseases can also cause similar symptoms.
What are the common symptoms of gastrointestinal lymphoma in our feline companions?
Cats with this type often vomit or have diarrhea.
They might lose weight fast, even if they’re eating.
You could notice a swollen or sore belly and changes in appetite.
If the kidneys are involved, thirst or urination might change too.
How does lymphoma affect a cat’s behavior and overall demeanor?
Some cats get more withdrawn or stop playing.
Hiding and signs of discomfort are common.
If the cancer affects the nerves or brain, they might act irritable or seem confused.
What are the signs that a cat with lymphoma is entering the final stages of the disease?
Late-stage lymphoma usually brings severe weakness and constant tiredness.
Cats may stop eating or drinking much at all.
Breathing can get difficult, and you might see swelling or even open sores.
Pain and discomfort tend to get worse at this point.
Do cats experience discomfort when they have gastrointestinal lymphoma?
Yes, cats can feel belly pain and nausea.
Ongoing digestive upset makes them uncomfortable.
You might notice your cat crying or acting restless because their stomach hurts.
They often eat less and lose weight, which probably comes from feeling bad.
If you want more details about treatment and how cats feel during this time, check out this study on owner perceptions of feline lymphoma treatment.