
Lymphoma is a pretty common cancer in cats, and it messes with their lymphatic system.
It might show up in different parts of the body, but it usually targets the digestive tract or the spinal cord.
The main thing to remember is that vets can diagnose lymphoma in cats with tests like biopsies, and there are treatments that can help cats live longer.
You might notice your cat losing weight, throwing up, or having trouble walking, depending on where the cancer is.
Since this disease can look different in every cat, getting a solid diagnosis from your vet is really important.
Cats with feline leukemia virus (FeLV) face a higher risk for lymphoma.
This article breaks down the signs, diagnosis, and treatment options for lymphoma in cats.
Hopefully, it’ll help you know what to expect and how to support your cat through this tough time.
Understanding Lymphoma in Cats
Lymphoma is a type of cancer in cats that affects lymphocytes, which are a kind of white blood cell.
This cancer can pop up in different spots and will cause different symptoms depending on where it starts.
If cat owners know about the types, causes, and signs of lymphoma, they can catch problems early and get their cats treated.
What Is Lymphoma?
Lymphoma is a cancer that starts in lymphocytes, which are part of the immune system.
These cells usually fight off infections.
When they start growing out of control, tumors form and can mess with lymph nodes, organs, or other tissues.
In cats, lymphoma can show up in places like the lymph nodes, intestines, kidneys, or chest (mediastinum).
Sometimes, it hits several areas at once, which vets call multicentric lymphoma.
This is actually one of the most common cancers in cats, and it can be slow-growing or aggressive.
Common Types of Feline Lymphoma
Feline lymphoma comes in a few main types:
- Multicentric lymphoma affects lymph nodes all over the body.
- Gastrointestinal (intestinal) lymphoma is found in the stomach or intestines.
- Mediastinal lymphoma shows up in the chest.
- Renal lymphoma is found in the kidneys.
Vets also sort lymphoma by how fast the cancer cells grow.
Low-grade (small cell) lymphoma grows slowly and usually appears in the intestines.
High-grade (large cell) lymphoma grows much faster and tends to be more aggressive.
Large cell lymphoma often causes more serious symptoms and needs quick treatment.

Risk Factors and Causes
No one knows the exact cause of feline lymphoma, but some risk factors are pretty clear.
Cats with feline leukemia virus (FeLV) have a much higher risk.
Feline immunodeficiency virus (FIV) can also raise the risk.
Vaccinating against FeLV lowers the risk, and some studies show fewer cases in vaccinated cats.
Age and genetics might matter too, but FeLV is the biggest known factor.
Chronic inflammation, especially in the intestines, seems to be linked to intestinal lymphoma.
Clinical Signs of Lymphoma in Cats
Symptoms of lymphoma depend on where it is.
Common signs include:
- Weight loss
- Not eating much
- Tiredness
- Vomiting or diarrhea
- Swollen lymph nodes
- Trouble breathing (if it’s in the chest)
If lymphoma hits the kidneys, it can cause kidney failure.
Cats with intestinal lymphoma usually have stomach issues like vomiting or diarrhea.
At first, the signs might be pretty mild, but they usually get worse over time.
Keep an eye out for changes in your cat’s eating, energy, or body condition.
Early vet visits can really help with getting a diagnosis and starting treatment.
For more details about types and signs of lymphoma, check out this article on feline lymphoma diagnosis and staging.
Diagnosis and Treatment of Lymphoma
Vets need to run a bunch of tests to figure out where the cancer is and how far it’s gone.
Once they confirm lymphoma, treatment depends on the type and location.
Cats can react differently to treatments, so vets keep a close eye on side effects and look for signs of remission.
How Lymphoma Is Diagnosed
Diagnosis usually starts with a physical exam.

The vet checks for swollen lymph nodes and feels organs like the spleen, liver, and kidneys.
Blood tests, including a complete blood count and urinalysis, help check your cat’s overall health.
Vets use chest x-rays to spot lymphoma in the chest.
To confirm lymphoma, they collect samples of cells using a biopsy or a fine needle aspirate.
Lab experts study these samples to make sure it’s lymphoma and figure out what type it is.
Sometimes, the vet might suggest a bone marrow test, especially if they think the cancer has spread to the nervous system or through the lymphatic vessels.
Catching lymphoma early usually means better treatment results.
Treatment Options for Lymphoma
Most cats with lymphoma get chemotherapy.
It goes after cancer cells all through the body.
Common drugs include prednisone, prednisolone, and chlorambucil.
These meds can shrink tumors and slow down the cancer.
Radiation therapy might help if the lymphoma is in the nasal cavity or just in one area.
Surgery isn’t used that often but could be an option if the cancer is limited.
Treatment plans depend on where the lymphoma is, like in the lymph nodes, kidneys, or spleen.
The cat’s health and the cost of treatment also play a role in what gets picked.
Potential Side Effects and Remission
Chemotherapy and other meds can cause side effects like nausea, vomiting, and a lower appetite.
Some cats might have weaker immune systems and get infections more easily.
Steroids might make cats drink and pee more than usual.
With treatment, a lot of cats go into remission, meaning the cancer isn’t showing up on tests.
Remission can last months or even years, but regular check-ups are important to catch any return of the cancer.
Watch your cat closely for side effects or changes in appetite, behavior, or energy.
Let your vet know about any issues so they can help keep your cat comfortable.
Prognosis and Living with Lymphoma
The outlook depends on the type and stage of lymphoma, and how well your cat responds to treatment.
Some types, like those found in the nasal cavity, have better outcomes than lymphoma that spreads to the bone marrow or nervous system.
Cats in remission can still have good lives with the right care and medication.
Regular vet visits help keep tabs on lymph nodes and organs.
It’s also smart to think about finances, since treatment and follow-ups can get pricey.
A good vet team can help you balance your cat’s quality of life with treatment choices.
Frequently Asked Questions
Lymphoma in cats can look pretty different depending on where it is.
Treatment choices change based on type and stage.
Knowing some basics can help you support your cat through this.
What are the common symptoms indicating a cat might have lymphoma?
Cats with lymphoma often lose weight and stop eating as much.
Vomiting or diarrhea can happen too.
Swollen lymph nodes or trouble breathing might show up as well.
How is lymphoma treated in feline patients?
Vets usually treat lymphoma with chemotherapy.
It often uses more than one drug, given over several weeks or months.
Some cats do really well and live longer with treatment.
Can you describe the symptoms of gastrointestinal lymphoma in cats?
Gastrointestinal lymphoma can cause vomiting, diarrhea, and weight loss.
Some cats might have a swollen belly or seem uncomfortable when you touch their stomach.
What conditions are commonly confused with lymphoma in cats?
Other illnesses like infections or inflammatory bowel disease can look a lot like lymphoma.
Vets need to run tests like biopsies or scans to know for sure.
Is there discomfort associated with gastrointestinal lymphoma in our feline friends?
Yes, cats with gastrointestinal lymphoma can feel pain or discomfort in their belly.
They might hide more or avoid being touched because of this.
What does the progression of lymphoma look like in cats towards the final stages?
In the late stages, most cats get very weak and often stop eating.
You might notice them having trouble breathing, or sometimes their organs start to fail.
At this point, comfort care really matters.
Learn more about lymphoma diagnosis and treatment in cats at Feline lymphoma: diagnosis, staging and clinical presentations.